甲氧基聚乙二醇-dibenzocyclooctyne (MPEG-DBCO)
甲氧基聚乙二醇-dibenzocyclooctyne (MPEG-DBCO)
名稱 | 貨號 | 英文名、縮寫 | 分子量 | 規(guī)格 | 價格 |
MPEG-DBCO | PS1-DB-5K | MPEG-ADIBO, MPEG-DBCO | 5000 | 0.1g、0.5g | 現(xiàn)詢 |
MPEG-DBCO | PS1-DB-2K | MPEG-ADIBO, MPEG-DBCO | 2000 | 0.1g、0.5g | 現(xiàn)詢 |
MPEG-DBCO | PS1-DB-1K | MPEG-ADIBO, MPEG-DBCO | 1000 | 0.1g、0.5g | 現(xiàn)詢 |
MPEG-DBCO | PS1-DB-10K | MPEG-ADIBO, MPEG-DBCO | 10000 | 0.1g、0.5g | 現(xiàn)詢 |
MPEG-DBCO | PS1-DB-20K | MPEG-ADIBO, MPEG-DBCO | 20000 | 0.1g、0.5g | 現(xiàn)詢 |
MPEG-DBCO | PS1-DB-30K | MPEG-ADIBO, MPEG-DBCO | 30000 | 0.1g、0.5g | 現(xiàn)詢 |
（備注：非常規(guī)分子量：350、500、550、750、1k。精確聚合度的小分子定制。）
結構式：
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基本信息：
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中文名稱：甲氧基聚乙二醇-dibenzocyclooctyne (MPEG-DBCO)
別名：MPEG-ADIBO, MPEG-DBCO
英文名稱：mPEG-DBCO ; mPEG-Dibenzocycolctyne
CAS：-
分子量：350、500、550、750、1K、2K、5K、10K、20K、30K
純度：95%以上
應用簡介：
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mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.
Copper-free Click reaction procedures:
Prepare the azide-containing reagents in reaction buffer.
Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
Purify conjugates either by dialysis or size-exclusion chromatograph.
物理性質：
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狀態(tài)：淡黃色到白色固體，或者半固體，取決于分子量。
溶解性：溶于水，乙醇，DMSO等溶劑。
保持條件：-20℃*保存，避光，干燥。
注意事項：取用一定要干燥，避免頻繁的溶解和凍干。
反應性：DBCO于含有N3基團的反應。
技術指標：
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純度（PEG）：95%以上
取代率（DBCO）：95%以上
分散系數(shù)（PDI）：小于等于1.05
分析：COA、GPC、NMR、MALDI-TOF
甲氧基聚乙二醇-dibenzocyclooctyne (MPEG-DBCO)
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