IITC 鉗式測(cè)痛儀是根據(jù) Randall-Selitto 理論設(shè)計(jì)，是進(jìn)行炎癥足加壓實(shí)驗(yàn)的經(jīng)典儀器。
型號(hào)2450型
根據(jù) Randall-Selitto 法，將藥物添加在小實(shí)驗(yàn)動(dòng)物的炎癥足上。Randall-Selitto 測(cè)痛儀測(cè)量單元具有壓力傳感器，并通過(guò)液晶屏實(shí)時(shí)顯示測(cè)量參數(shù)。壓力施加器一端為彈性的尖形探頭，另一端平坦。使用時(shí)將動(dòng)物足部放入壓力施加器中間，對(duì)準(zhǔn)探頭，施加壓力。逐步提高作用于動(dòng)物爪子上的機(jī)械壓力，逼近動(dòng)物的疼痛閾限，當(dāng)動(dòng)物出現(xiàn)縮足反應(yīng)時(shí)，儀器自動(dòng)測(cè)量并記錄壓力信號(hào)，以g為單位。
與熱痛不同，該儀器用于機(jī)械壓痛和鈍痛的痛覺(jué)測(cè)量，常用于辨別左右爪不同的痛覺(jué)反應(yīng)。
鉗式測(cè)痛儀的產(chǎn)品特點(diǎn)
適用于大鼠和小鼠精確度為0.01克
壓力400克數(shù)字顯示功能，實(shí)時(shí)壓力、值，單位為g
配置腳踏控制器，控制啟動(dòng)下次實(shí)驗(yàn)，解放雙手，提高實(shí)驗(yàn)效率可選的動(dòng)物固定支架，可輕松固定動(dòng)物
方便操作測(cè)量誤差小于0.5%，不需校準(zhǔn)，采用RS-232輸出方式
鉗式測(cè)痛儀 Rodent Pincher Analgesia Meter
Rodent Pincher allows researchers to measure and test pain threshold in a simple, accurate method when measuring pain nociception.
The system can be used on mice or rats and will measure and display in grams the amount of force that has been applied to the animals paw.
Accuracy is .01 grams, no calibration needed.
One year warranty, CE certified
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相關(guān)文獻(xiàn)
[HTML] Coupled activation of primary sensory neurons contributes to chronic pain
YS Kim, M Anderson, K Park, Q Zheng, A Agarwal… - Neuron, 2016 - Elsevier
… reported low incidence of neuron-neuron dye-coupling after CFA injection in the mouse paw
and … of naive, CFA, CFA with CBX, sham, SN-CCI, and SN-CCI with CBX animals by rodent pincher … CreER mice, which is present in glial cells in the peripheral nervous system such as …
[HTML] Imaging large-scale cellular activity in spinal cord of freely behaving mice
KJ Sekiguchi, P Shekhtmeyster, K Merten… - Nature …, 2016 -
… was recorded during rest (left) and following cutaneous stimulation with a rodent pincher applied
to … Mouse running speed (black) and tail pinch application (purple) is shown on top … Previous studies
in anaesthetized rodents, using two-photon imaging of non-selective synthetic or …
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model
R Sarabia-Estrada, A Ruiz-Valls, SR Shah… - … of Neurosurgery: Spine, 2017 - thejns.org
… Nociceptive response was evaluated using the rodent pincher analgesia meter (Part # 2450,
IITC Life Science … chordoma models derived from human tissues have been used to produce rodent
tumors; however … is a lack of studies on pathologic gait due to chordomas in rodents …
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