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商鋪產(chǎn)品:200條

所在地區(qū):上海上海市

聯(lián)系人:李經(jīng)理 (經(jīng)理)

公司動態(tài)

Rabbit Anti-11β-HSD2

閱讀:123發(fā)布時間:2012-8-24

 

Rabbit Anti-11β-HSD2
FROM:ABCAM
Catalog Number : HZ982114        
Quantity size :   0.2ml (dilute with pH 7.4    0.01 M PBS or antibody diluent )
 
Background:  Glucocorticoid hormone action in target tissues is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD), which catalyzes the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone). At least two isoforms of 11β-HSD exist a low-affinity NADP-dependent dehydrogenase/oxoreductase (11β-HSD2) and a high-affinity NAD-dependent dehydrogenase (11β-HSD2). The glycosylated 11β-HSD2 protein activates cortisol from cortisone, which is widely expressed in mammals, and is most highly expressed in the liver . 11β-HSD2 inactivates cortisol to cortisone and is expressed in placenta, aldosterone target tissues (kidney, parotid, colon and skin) and pancreas. 11β-HSD2 may play a role in glucose homeostasis and pathogenesis of a number of disorders including insulin resistance and obesity. 11β-HSD2 associates with differentiation or maturation in human colonic epithelia and may serve as a marker in development and disease. In addition, 11β-HSD2 plays a crucial role in modulating mineralcorticoid and glucocorticoid receptor occupancy by glucocorticoids.
 
pecificity :   
        Anti- 11β-HSD2  is a rabbit monoclonal antibody unconjugated                
         specific for 11β-HSD2 of human, mouse, rat          
         use for western blotting,elisa,immunoprecipitation and immunohistochemistry
         Protein G affinity chromatography purification, purity :>95%
         Isotype:  IgG
         mol wt:  34kDa
 
Rabbit Anti-11β-HSD2
Application :  
        Western blotting 1:100-500                
         Immunohistochemistry 1:100-500                 
         ELISA 1:500-1000                  
         Optimal working dilutions must be determined by the end user.
 
Storage: Store at -20 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4
 
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rabbit Anti-11β-HSD2


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