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當(dāng)前位置:珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品(上海)有限公司>>>>AF-DX 384, [2,3-Dipropylamino-3H]-, 250µCi (9.25MBq)

AF-DX 384, [2,3-Dipropylamino-3H]-, 250µCi (9.25MBq)

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更新時間:2022-10-15 15:33:51瀏覽次數(shù):87次

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產(chǎn)品簡介

AFDX-384 (BIBN-161) radioligand tritiated at the 2,3-dipropylamino position. AFDX-384 acts as a selective antagonist of muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes.

詳細(xì)介紹

AFDX-384 is a drug targeting M2 and M4 muscarinic receptors, and is used for mapping receptor distribution in the brain. Muscarinic acetylcholine receptors (mAChRs) are GPCRs that play a role in the parasympathetic nervous system. Muscarinic acetylcholine receptors are potential targets for dementia and schizophrenia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1041:

  1. A.V. Terry, D.A. Gearhart, S.P. Mahadik, S. Warsi, J.L. Waller, Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain, In Neuroscience, Volume 140, Issue 4, 2006, Pages 1277-1287.

規(guī)格

檢測方法 Radiometric
標(biāo)簽位置 Specifically Labeled
分子量 478.6
產(chǎn)品品牌名稱 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受體類型 Acetylcholine (Muscarinic)
運輸條件 干冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域 CNS & Neurologic, Cardiovascular, Gastrointestinal
產(chǎn)品尺寸 250 µCi

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