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當(dāng)前位置：珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品（上海）有限公司>>>>SCH 23390, [N-Methyl-3H]-, 250µCi (9.25MBq)

SCH 23390, [N-Methyl-3H]-, 250µCi (9.25MBq)

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商鋪產(chǎn)品：677條

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SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.

詳細(xì)介紹

SCH-23390 acts as an antagonist at the dopamine D1 receptor. These receptors belong a family of GPCRs and are potential drug targets for Parkinson's disease, schizophrenia, and depression.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET930:

  1. Finnema, S.J., Bang-Andersen, B., J?rgensen, M., Christoffersen, C.T., Gulyás, B., Wikstr?m, H.V., Farde, L. and Halldin, C. (2013), The dopamine D1 receptor agonist (S)-[11C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration—a positron emission tomography examination in the monkey brain. Synapse, 67: 586–595.
  2. Wong, J., Clifford, J., Massalas, J., Finkelstein, D., Horne, M., Waddington, J., Drago, J. (2003) Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice, European Journal of Pharmacology, 472 (1–2): 39-47.

規(guī)格

濃度 1.0 - 10 mCi/mL
檢測(cè)方法 Radiometric
標(biāo)簽位置 Specifically Labeled
分子量 287.8
產(chǎn)品品牌名稱 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受體類型 Dopamine
運(yùn)輸條件 干冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域 CNS & Neurologic
產(chǎn)品尺寸 250 µCi

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