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CORTECS C8 Column

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CORTECS C8柱的疏水保留性更低，因此有利于強(qiáng)疏水性化合物的分離與分析

詳細(xì)介紹

C8柱更大化效率與通量

CORTECS C8柱是CORTECS家族的另一新成員。與典型C18柱相比，CORTECS C8柱的疏水保留性更低，因此有利于強(qiáng)疏水性化合物的分離與分析。CORTECS C8柱還適用于將常規(guī)C8柱HPLC方法轉(zhuǎn)換/升級(jí)到更耐用的色譜柱技術(shù)。

CORTECS C8柱的優(yōu)勢(shì)：

將常規(guī)C8柱HPLC方法轉(zhuǎn)換至更為穩(wěn)定耐用的色譜柱技術(shù)
與典型C18柱相比，疏水保留性較低
低pH條件下鍵合相穩(wěn)定
兼容LC-MS

使用CORTECS C8 色譜柱根據(jù)USP方法分析中的雜質(zhì)

政府監(jiān)管機(jī)構(gòu)要求制藥公司必須根據(jù)美國(guó)藥典(USP)中的標(biāo)準(zhǔn)對(duì)藥物制劑化合物進(jìn)行分析。USP方法通常采用內(nèi)徑4.6 mm、填充顆粒直徑在3 µm以上的大尺寸色譜柱，使得分析時(shí)間非常長(zhǎng)，且流動(dòng)相消耗量非常大。要想縮短運(yùn)行時(shí)間，進(jìn)而縮短周轉(zhuǎn)時(shí)間和減少溶劑消耗量，方法之一就是將原始USP方法轉(zhuǎn)換至填充有高柱效實(shí)心核顆粒的小尺寸色譜柱1 ，而CORTECS色譜柱正是進(jìn)行這種方法革新的理想之選。該系列色譜柱采用了含有多種鍵合配體基團(tuán)的實(shí)心核顆粒，苯基和C8 填料是 CORTECS產(chǎn)品系列的成員。這些新的填料可分別用于革新USP指導(dǎo)原則中使用L11和L7色譜柱的方法，能夠在不影響柱效的前提下縮短運(yùn)行時(shí)間。在本應(yīng)用中，我們將分析中雜質(zhì)的USP方法分別轉(zhuǎn)換至三種不同的色譜柱。方法轉(zhuǎn)換過程選用了3種不同粒徑的色譜柱，并以 USP通用章節(jié)<621>作為指導(dǎo)。

品名	編號(hào)
CORTECS HILIC Column, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg	176003286
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 50 mm, 3/pkg	176003810
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 100 mm, 3/pkg	176003812
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 150 mm, 3/pkg	176003813
CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 30 mm, 3/pkg	176003834
CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 50 mm, 3/pkg	176003835
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 30 mm, 1/pkg	186008358
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 50 mm, 1/pkg	186008359
CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 50 mm, 1/pkg	186008409
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 75 mm, 1/pkg	186008350
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 100 mm, 1/pkg	186008351
CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 30 mm, 1/pkg	186008408
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 150 mm, 1/pkg	186008352
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 100 mm, 3/pkg	176003807
CORTECS C8 Column, 90?, 1.6 µm, 3 mm X 75 mm, 1/pkg	186008410
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 150 mm, 3/pkg	176003808
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 30 mm, 3/pkg	176003809
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 30 mm, 3/pkg	176003804
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 50 mm, 3/pkg	176003805
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 75 mm, 3/pkg	176003806
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 50 mm, 1/pkg	186008349
CORTECS C8 Column, 90?, 2.7 µm, 2.1 mm X 30 mm, 1/pkg	186008348
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 150 mm, 1/pkg	186008362
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 100 mm, 1/pkg	186008361
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 150 mm, 3/pkg	176003818
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 30 mm, 3/pkg	186008403
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 50 mm, 3/pkg	186008404
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 30 mm, 3/pkg	176003814
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 50 mm, 3/pkg	176003815
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 75 mm, 3/pkg	176003816
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 100 mm, 3/pkg	176003817
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg	176003811
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 30 mm, 3/pkg	186008353
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 100 mm, 3/pkg	186008356
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 150 mm, 3/pkg	186008357
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 100 mm, 1/pkg	186008371
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 150 mm, 1/pkg	186008372
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 100 mm, 3/pkg	186008406
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 75 mm, 3/pkg	186008405
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 75 mm, 1/pkg	186008370
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 2.1 mm X 150 mm, 3/pkg	186008407
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 50 mm, 3/pkg	186008414
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 75 mm, 3/pkg	186008415
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 30 mm, 3/pkg	186008413
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 30 mm, 1/pkg	186008368
CORTECS C8 Column, 90?, 2.7 µm, 4.6 mm X 50 mm, 1/pkg	186008369
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 150 mm, 3/pkg	186008417
CORTECS C8 Method Validation Kit, 90?, 1.6 µm, 3 mm X 100 mm, 3/pkg	186008416
CORTECS C8 Column, 90?, 2.7 µm, 3 mm X 75 mm, 1/pkg	186008360
CORTECS C8 VanGuard Cartridge, 90?, 2.7 µm, 2.1 mm X 5 mm, 3/pkg	186008421
CORTECS C8 VanGuard Cartridge, 90?, 2.7 µm, 3.9 mm X 5 mm, 3/pkg	186008422
CORTECS C8 VanGuard Pre-column, 90?, 1.6 µm, 2.1 mm X 5 mm, 3/pkg	186008423
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 50 mm, 3/pkg	186008354
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 2.1 mm X 75 mm, 3/pkg	186008355
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 75 mm, 3/pkg	186008375
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 100 mm, 3/pkg	186008376
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 150 mm, 3/pkg	186008377
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 30 mm, 3/pkg	186008373
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 4.6 mm X 50 mm, 3/pkg	186008374
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 100 mm, 3/pkg	186008366
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 150 mm, 3/pkg	186008367
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 50 mm, 3/pkg	186008364
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 75 mm, 3/pkg	186008365
CORTECS C8 Method Validation Kit, 90?, 2.7 µm, 3 mm X 30 mm, 3/pkg	186008363