汽化過氧化氫(VHP)生物滅菌技術(shù)

      汽化過氧化氫(VHP)生物滅菌技術(shù)是一種在常溫狀態(tài)下將液態(tài)過氧化氫轉(zhuǎn)換成汽態(tài)過氧化氫的滅菌消毒方法。
      其主要特點是作用快速、滅活率高、無毒無殘留，無乙酸、環(huán)氧乙烷或甲醛對于物體表面的高腐蝕性等*性,正迅速成為制藥、生物技術(shù)和醫(yī)療衛(wèi)生行業(yè)生物凈化方法的選擇，對與濕熱滅菌柜相同的生物指示劑- 嗜熱脂肪芽孢桿菌達到6-log 的殺滅率。這種滅菌方式目前已廣泛應(yīng)用于制藥、生物科技、生物醫(yī)學、衛(wèi)生保健、生物、食品和環(huán)境保護等領(lǐng)域。
      適用于房間、生物安全柜、傳遞窗、動物籠交換站、隔離器和醫(yī)療器械等表面的滅菌消毒。汽化過氧化氫(VHP)于1990年已被美國EPA(美國環(huán)境保護署)注冊為一種滅菌劑，由35%雙氧水通過VHP發(fā)生器汽化產(chǎn)生，實驗證明：汽化狀態(tài)的雙氧水，其殺滅細菌芽孢的能力約為液態(tài)雙氧水大于200倍。
      2011年瑞典倫德大學臨床科學系傳染疾病組和瑞典倫德大學醫(yī)學檢驗系微生物醫(yī)學組在瑞典馬爾默斯堪大學醫(yī)院進行的"汽化過氧化氫與干霧滅菌系統(tǒng)比較"試驗的結(jié)論中提到了：汽化過氧化氫可以對細菌孢子達到 6‐log 的殺滅率，包括艱難梭菌以及其他醫(yī)院常見細菌，如 MRSA, VRE，鮑氏不動桿菌以及病毒。汽化過氧化氫滅菌后，通過對表面取樣顯示其可以*艱難梭菌等醫(yī)院常見病菌的病原體。 還有些研究也表明在使用汽化過氧化氫對暴發(fā)性疫情進行控制時，其可以有效減少艱難梭菌的感染。汽化過氧化氫對于院感細菌的滅活率強。
      該文中也指出:有充分證據(jù)表明被感染的表面是院內(nèi)致病菌感染傳播的重要因素，包括艱難梭狀芽孢桿菌，抗藥性金黃色葡萄球菌（MRSA）耐萬古霉素腸球菌（VRE）和鮑氏不動桿菌。 即便在傳統(tǒng)方法清潔后，病房表面也經(jīng)常發(fā)現(xiàn)有病菌感染。因此，如果前一個病人上述病菌呈陽性，新病人入住后，會有很大風險感染這些致病菌。
      針對于目前醫(yī)院感染病房,急救車,疾控,制藥廠等環(huán)境滅菌消毒非常有效。

HYDROGEN PEROXIDE VAPOUR Sterilizer

HYDROGEN PEROXIDE VAPOUR was registered as a type of high efficient sterilization agent by EPA in 1990year. 

2011, In Lund University, Skane University Hospital SUS, Malmo Sweden was conducted a head-to-head in vitro comparison of a hydrogen peroxide vapor(HYDROGEN PEROXIDE VAPOUR) system and an aerosolized hydrogen peroxide(aHP) system. One of its conclusion mentioned that the HYDROGEN PEROXIDE VAPOUR achieves a 6-log reduction on bacterial endospores, including C.Difficile; common hospital bacteria such as MRSA, VRE, and A. Baumannii and viruses.  Surface sampling after HYDROGEN PEROXIDE VAPOUR shows that it usually eradicates contamination with C. difficile and other hospital pathogens.  Several studies have linked the use of HYDROGEN PEROXIDE VAPOUR with the control of outbreaks, and the use of HYDROGEN PEROXIDE VAPOUR has been shown to reduce the incidence of C.difficile infection.
It also pointed that: there is now good evidence that contaminated surfaces make a significant contribution to the transmission of nosocomial pathogens including Clostridium difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci(VRE) and Acinetobacter baumannii. Surfaces in patient areas have frequently been found to be contaminated after conventional cleaning, and, linked to these findings, patients admitted to rooms previously occupied by patients positive for VRE, MRSA, A.baumannii, and Pseudomonas aeruginosa are at increased risk of acquiring these pathogens.  Given these findings, several area decontamination methods have emerged. These methods do not rely on the operator to distribute the active substance; thereby, they can achieve coverage of all surfaces in a room and are likely to be more repeatable than conventional methods.